Estradiol distearate
Estradiol distearate is a synthetic estrogen and a chemical compound that is a diester of estradiol with stearic acid. It is used in hormone replacement therapy and other medical applications.
Chemical Structure[edit | edit source]
Estradiol distearate is formed by the esterification of the two hydroxyl groups of estradiol with stearic acid. This results in a molecule with two long-chain fatty acid esters attached to the estradiol backbone.
Pharmacology[edit | edit source]
As an estrogen, estradiol distearate mimics the effects of natural estradiol in the body. It binds to estrogen receptors and modulates the expression of genes involved in the development and maintenance of female reproductive tissues, secondary sexual characteristics, and other physiological processes.
Medical Uses[edit | edit source]
Estradiol distearate is primarily used in hormone replacement therapy (HRT) for the treatment of symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. It may also be used in the treatment of certain hormone-sensitive cancers and in transgender hormone therapy.
Administration[edit | edit source]
Estradiol distearate can be administered via various routes, including oral administration, transdermal patches, and intramuscular injections. The choice of administration route depends on the specific medical condition being treated and patient preferences.
Side Effects[edit | edit source]
Common side effects of estradiol distearate include nausea, headache, breast tenderness, and weight gain. More serious side effects can include an increased risk of thrombosis, stroke, and breast cancer. Patients are advised to discuss the risks and benefits of estradiol distearate with their healthcare provider.
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References[edit | edit source]
External Links[edit | edit source]
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