Estradiol stearate

Estradiol stearate is a synthetic, steroidal estrogen that is used in hormone therapy. It is an ester of estradiol, the primary female sex hormone, and stearic acid, a saturated fatty acid. Estradiol stearate is used in a variety of medical applications, including the treatment of menopausal symptoms, hypoestrogenism, and certain types of breast cancer.

Pharmacology

Estradiol stearate is a prodrug of estradiol, meaning it is metabolized in the body to produce estradiol. This process occurs through the action of esterases, enzymes that break down esters into their component parts. Once metabolized, the estradiol produced has the same effects as naturally occurring estradiol in the body.

Medical Uses

Estradiol stearate is used in hormone therapy for menopausal symptoms such as hot flashes and vaginal dryness. It is also used to treat hypoestrogenism, a condition characterized by low levels of estrogen in the body. In addition, estradiol stearate is used in the treatment of certain types of breast cancer that are responsive to estrogen.

Side Effects

Like all medications, estradiol stearate can cause side effects. These may include nausea, bloating, breast tenderness, and headache. More serious side effects can include blood clots, stroke, and an increased risk of certain types of cancer.

See Also

• Estradiol
• Estrogen
• Hormone therapy
• Menopause
• Breast cancer

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