Estrazinol

Estrazinol (also known as Estradiol azine or Estradiol 3,17β-diacetate 3,17β-diazine) is a synthetic, steroidal estrogen that was never marketed. It is an estrogen ester – specifically, the 3,17β-diacetate 3,17β-diazine of estradiol.

Chemistry

Estrazinol, also known as estradiol 3,17β-diacetate 3,17β-diazine, is a synthetic estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. It is an estrogen ester in that it is a prodrug of estradiol in the body. Estrazinol is a steroid and is also known by its systematic name, which is (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 3,17-diacetate 3,17-diazine.

Pharmacology

As a prodrug of estradiol, estrazinol has estrogenic activity. It is administered by injection and has a long duration of action due to its ester nature.

History

Estrazinol was never marketed. The reason for this is not entirely clear, but it may be due to its synthetic nature and the availability of other, more established estrogens.

See also

• List of estrogen esters
• List of synthetic estrogens