Estrazinol

Estrazinol (also known as Estradiol azine or Estradiol 3,17β-diacetate 3,17β-diazine) is a synthetic, steroidal estrogen that was never marketed. It is an estrogen ester – specifically, the 3,17β-diacetate 3,17β-diazine of estradiol.

Chemistry[edit | edit source]

Estrazinol, also known as estradiol 3,17β-diacetate 3,17β-diazine, is a synthetic estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. It is an estrogen ester in that it is a prodrug of estradiol in the body. Estrazinol is a steroid and is also known by its systematic name, which is (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 3,17-diacetate 3,17-diazine.

Pharmacology[edit | edit source]

As a prodrug of estradiol, estrazinol has estrogenic activity. It is administered by injection and has a long duration of action due to its ester nature.

History[edit | edit source]

Estrazinol was never marketed. The reason for this is not entirely clear, but it may be due to its synthetic nature and the availability of other, more established estrogens.