Ethinylestradiol sulfamate

Ethinylestradiol sulfamate (also known as EES, estradiol sulfamate, or E2S) is a steroidal estrogen that is used in hormone replacement therapy and as a component of hormonal contraception. It is a synthetic, steroidal estrogen and a sulfamate ester of ethinylestradiol.

Pharmacology[edit]

Ethinylestradiol sulfamate is a prodrug of ethinylestradiol, which means it is converted into ethinylestradiol in the body. The sulfamate ester group makes the molecule more water-soluble and increases its oral bioavailability. It also slows down the metabolism of the drug, allowing it to have a longer duration of action.

Medical uses[edit]

Ethinylestradiol sulfamate is used in hormone replacement therapy for menopausal symptoms and in hormonal contraception to prevent pregnancy. It is usually combined with a progestogen to reduce the risk of endometrial hyperplasia and endometrial cancer.

Side effects[edit]

Like other estrogens, ethinylestradiol sulfamate can cause a range of side effects, including nausea, breast tenderness, headaches, and mood changes. It can also increase the risk of certain serious health problems, such as blood clots, stroke, and certain types of cancer.