Ethylcholine mustard

Ethylcholine mustard

Ethylcholine mustard (also known as ECM) is a chemical compound that belongs to the class of alkylating agents. It is a derivative of choline and is used in scientific research, particularly in the field of neuroscience and pharmacology.

Chemical Structure

Ethylcholine mustard is a quaternary ammonium compound. It consists of a choline molecule that has been modified by the addition of an ethyl group and a mustard group. The ethyl group is attached to the nitrogen atom of the choline molecule, while the mustard group is attached to the oxygen atom.

Mechanism of Action

As an alkylating agent, ethylcholine mustard works by transferring its alkyl group to other molecules. In the context of neuroscience research, it is often used to alkylate acetylcholine receptors, thereby blocking their function. This can be useful in studies investigating the role of these receptors in various neurological processes.

Applications in Research

Ethylcholine mustard has been used in a variety of research contexts. For example, it has been used to study the effects of acetylcholine receptor blockade on neurotransmission and neuronal plasticity. It has also been used in research investigating the role of acetylcholine receptors in diseases such as Alzheimer's disease and myasthenia gravis.

Safety and Toxicity

Like other alkylating agents, ethylcholine mustard can be hazardous if not handled properly. It can cause skin and eye irritation, and may be harmful if swallowed or inhaled. Therefore, it should be used with caution in a laboratory setting, and appropriate safety measures should be taken.

See Also

• Alkylating agent
• Choline
• Acetylcholine receptor
• Neurotransmission
• Neuronal plasticity