Ethylestrenol

Ethylestrenol, also known by its developmental code name Orgasteron and sold under the brand name Maxibolin among others, is an anabolic steroid that was first described in 1960 and introduced for medical use in 1964. It is an orally active 17α-alkylated derivative of nandrolone (19-nortestosterone). Ethylestrenol is used in the treatment of conditions associated with catabolism and tissue wasting, such as chronic debilitating diseases, recovery from major surgery, and osteoporosis. Despite its medical applications, its use has been limited due to its weak anabolic effects and it has been largely replaced by more potent anabolic steroids.

Medical Uses

Ethylestrenol is indicated for the treatment of conditions that require a mild anabolic agent, such as chronic obstructive pulmonary disease (COPD), osteoporosis, and certain cases of anemia. It has also been used to promote weight gain after surgery, chronic infections, or severe trauma.

Pharmacology

Mechanism of Action

As an anabolic steroid, ethylestrenol exerts its effects by binding to and activating the androgen receptor (AR). This leads to an increase in protein synthesis and an overall anabolic effect in muscle and bone tissue. However, its affinity for the AR is significantly lower than that of testosterone and other more potent anabolic steroids, which accounts for its relatively weak anabolic effects.

Pharmacokinetics

Ethylestrenol is well absorbed from the gastrointestinal tract, but it undergoes significant first-pass metabolism in the liver, which reduces its bioavailability. Its 17α-alkylated structure, however, helps it resist complete breakdown by the liver, allowing a portion of the drug to enter circulation and exert its effects.

Adverse Effects

The adverse effects of ethylestrenol are similar to those of other anabolic steroids and can include liver toxicity, changes in lipid profiles, and potential effects on cardiovascular health. Due to its relatively weak anabolic activity, the risk of severe side effects is lower compared to more potent anabolic steroids. However, long-term use or high doses can still lead to significant health risks.

Legal Status

The legal status of ethylestrenol varies by country. In some jurisdictions, it is classified as a controlled substance, which restricts its use and distribution. Its non-medical use, such as for bodybuilding or performance enhancement, is generally prohibited.

See Also

• Anabolic steroid
• Nandrolone
• Androgen receptor
• Liver toxicity
• Lipid profile