Evx2
Evx2 (even-skipped homeobox 2) is a gene that plays a crucial role in the development of vertebrates. It is part of the homeobox gene family, which is known for its involvement in regulating patterns of anatomical development (morphogenesis) in animals, fungi, and plants. Evx2 is particularly important in the development of the vertebrate nervous system and limb formation.
Function[edit | edit source]
Evx2 is a homeobox gene, which means it contains a specific DNA sequence known as a homeobox. This sequence encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. The Evx2 gene is closely related to the even-skipped (eve) gene found in Drosophila melanogaster, a model organism commonly used in genetic studies.
In vertebrates, Evx2 is expressed in the developing spinal cord and is involved in the differentiation of motor neurons. It is also expressed in the developing limbs, where it plays a role in patterning and growth. The precise regulation of Evx2 expression is critical for normal development, and disruptions in its expression can lead to developmental abnormalities.
Genomic Location[edit | edit source]
In humans, the Evx2 gene is located on chromosome 2, in a region that is syntenic with the HoxD cluster. This proximity to the HoxD cluster suggests that Evx2 may be co-regulated with Hox genes, which are also involved in developmental patterning.
Clinical Significance[edit | edit source]
Mutations or misregulation of Evx2 can lead to developmental disorders. For example, alterations in Evx2 expression have been implicated in limb malformations and spinal cord defects. Understanding the role of Evx2 in development can provide insights into congenital conditions and potential therapeutic targets.
Research[edit | edit source]
Research on Evx2 involves studying its expression patterns, regulatory mechanisms, and interactions with other genes during development. Model organisms such as mice and zebrafish are often used to investigate the function of Evx2, as they allow for genetic manipulation and observation of developmental processes.
Also see[edit | edit source]
 | This genetics article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
