Ezetimibe/atorvastatin

Ezetimibe/atorvastatin is a medication used in the treatment of high cholesterol. It is a combination of two drugs, ezetimibe and atorvastatin, which work together to lower the levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Etymology[edit | edit source]

The name "ezetimibe" is derived from the chemical name "(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one". The name "atorvastatin" comes from the chemical name "[[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid]]".

Pharmacology[edit | edit source]

Ezetimibe works by reducing the amount of cholesterol absorbed by the body, while atorvastatin inhibits an enzyme in the liver that produces cholesterol. The combination of these two drugs is more effective at lowering cholesterol levels than either drug alone.

Uses[edit | edit source]

Ezetimibe/atorvastatin is used to treat high cholesterol and to reduce the risk of heart disease, stroke, and other cardiovascular diseases. It is typically prescribed to patients who have not been able to lower their cholesterol levels through diet and exercise alone.

Side Effects[edit | edit source]

Common side effects of ezetimibe/atorvastatin include headache, muscle pain, and diarrhea. Serious side effects can include liver problems and a rare but serious muscle condition called rhabdomyolysis.

Related Terms[edit | edit source]

Ezetimibe/atorvastatin Resources
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