F2RL2

F2RL2 or Protease-activated receptor 3 is a protein that in humans is encoded by the F2RL2 gene. This protein belongs to the protease-activated receptor (PAR) family which is a subfamily of related G protein-coupled receptors (GPCRs). Protease-activated receptors are involved in a number of cellular processes, including inflammation, neurodegeneration, pain, and coagulation.

Function

F2RL2 is activated by thrombin and trypsin but not by activated protein C and other coagulation and fibrinolytic factors. It is expressed in various tissues such as the heart, lung, and kidney. The activation of this receptor leads to phosphoinositide hydrolysis, mobilization of intracellular calcium, mitogen-activated protein kinase activation, and cell proliferation.

Clinical significance

Alterations in the F2RL2 gene have been associated with various diseases. For instance, mutations in this gene have been linked to bleeding disorders due to a decrease in thrombin signaling. Moreover, F2RL2 has been implicated in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and asthma.

See also

• Protease-activated receptor
• G protein-coupled receptor
• Thrombin
• Trypsin

References

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