FABP2

FABP2 or Fatty Acid Binding Protein 2 is a protein that in humans is encoded by the FABP2 gene. It is also known as Intestinal Fatty Acid Binding Protein (I-FABP). FABP2 is expressed in the absorptive enterocytes of the small intestine and plays an important role in the absorption and intracellular transport of dietary long-chain fatty acids.

Function

FABP2 is involved in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. It may also be responsible for the modulation of the activity of enzymes involved in the metabolism of fatty acids. FABP2 binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. It may be involved in intracellular lipid transport.

Clinical significance

Variations in the FABP2 gene have been associated with Type 2 diabetes and Insulin resistance. A specific allele of this gene has been found to be associated with an increased risk of insulin resistance and type 2 diabetes.

See also

• Fatty acid-binding protein
• FABP1
• FABP3
• FABP4
• FABP5
• FABP6
• FABP7

External links

• FABP2 at the US National Library of Medicine Medical Subject Headings (MeSH)

FABP2 Resources
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