FGF1

FGF1‏‎ or Fibroblast Growth Factor 1 is a protein that in humans is encoded by the FGF1 gene. It is a member of the fibroblast growth factor (FGF) family, which is involved in a variety of biological processes.

Function

FGF1 is a potent stimulator of angiogenesis (the formation of new blood vessels) and has been associated with wound healing and tissue repair. It is also involved in embryonic development and the growth and differentiation of cells and tissues. FGF1 binds to fibroblast growth factor receptor (FGFR), which leads to receptor dimerization and activation of its intrinsic tyrosine kinase activity.

Clinical significance

Mutations in the FGF1 gene have been associated with various diseases, including Kallmann syndrome, a disorder characterized by hypogonadotropic hypogonadism and anosmia. FGF1 has also been implicated in the development of certain types of cancer, including breast cancer and prostate cancer.

Therapeutic potential

Due to its role in angiogenesis, FGF1 has potential therapeutic applications in the treatment of conditions such as coronary artery disease and peripheral artery disease. It has also been investigated for its potential use in regenerative medicine, particularly in the healing of wounds and burns.

See also

• Fibroblast growth factor
• Fibroblast growth factor receptor
• Angiogenesis
• Kallmann syndrome
• Breast cancer
• Prostate cancer
• Coronary artery disease
• Peripheral artery disease