FGF17
FGF17 or Fibroblast Growth Factor 17 is a protein that in humans is encoded by the FGF17 gene. It is a member of the Fibroblast Growth Factor (FGF) family, which is involved in a variety of biological processes, including cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
Function[edit | edit source]
FGF17 is a secreted protein that binds to FGFR2b and FGFR3c. It plays an essential role in the regulation of embryonic development, cell proliferation, cell differentiation, and cell migration. FGF17 is required for normal brain, eye, ear and limb development during embryogenesis. It is also required for normal development of the cerebellum and the cortex.
Clinical Significance[edit | edit source]
Mutations in the FGF17 gene and its related pathways have been associated with a variety of diseases and disorders. For example, alterations in FGF17 expression have been implicated in cancer development and progression. Additionally, FGF17 has been linked to developmental disorders such as Kallmann syndrome, a condition characterized by delayed or absent puberty and an impaired sense of smell.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
