FGF2
FGF2 or Fibroblast Growth Factor 2 is a type of protein and a member of the Fibroblast Growth Factor (FGF) family. It is also known as basic fibroblast growth factor (bFGF) and FGF-β. FGF2 plays a crucial role in cell proliferation, cell differentiation, and angiogenesis, which is the formation of new blood vessels from pre-existing ones.
Function[edit | edit source]
FGF2 is a potent modulator of cell growth and cell differentiation. It is involved in a variety of biological processes, including embryonic development, tissue repair, tumor growth, and invasion. FGF2 achieves its functions by binding to its receptors, known as FGF receptors (FGFRs), which triggers a cascade of downstream signal transduction pathways.
Structure[edit | edit source]
FGF2 is a single-chain polypeptide composed of 146 amino acids. It lacks a signal peptide, which is unusual for a secreted protein. Instead, FGF2 is exported from cells by a non-classical pathway, which is not yet fully understood.
Clinical Significance[edit | edit source]
Due to its role in cell growth and differentiation, FGF2 has been implicated in a variety of diseases, including cancer, diabetes, and atherosclerosis. It is also being investigated for its potential use in tissue engineering and regenerative medicine.
See Also[edit | edit source]
References[edit | edit source]
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