FIZ1

FIZ1 (FIZZ1 or Found In Inflammatory Zone 1) is a protein that in humans is encoded by the RETNLB gene. It is also known as RELM beta (Resistin-like molecule beta). FIZ1 is a member of the resistin family of hormones and is primarily associated with inflammation and immune response.

Function

FIZ1 is a cytokine hormone that is secreted by various cells, including macrophages and epithelial cells. It is involved in several biological processes, including inflammation, immune response, and cell proliferation. FIZ1 is also implicated in the pathogenesis of several diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.

Structure

The FIZ1 protein is a small, cysteine-rich, secreted protein. It is characterized by a unique 10-cysteine residue motif with a highly conserved pattern. The structure of FIZ1 is similar to that of other members of the resistin family.

Clinical significance

FIZ1 has been found to be overexpressed in several types of cancer, including lung cancer, colorectal cancer, and breast cancer. It is believed to promote tumor growth and metastasis by enhancing cell proliferation and survival. In addition, FIZ1 is also involved in the pathogenesis of several inflammatory diseases, such as asthma and COPD. It is thought to contribute to these diseases by promoting inflammation and immune response.

Research

Research is ongoing to further understand the role of FIZ1 in disease and to explore its potential as a therapeutic target. Several studies have shown that blocking the activity of FIZ1 can reduce inflammation and tumor growth in animal models.

See also

• Resistin
• Cytokine
• Inflammation
• Immune response

References

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