FLRT1

FLRT1 or Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. It is a member of the fibronectin leucine rich transmembrane protein (FLRT) family.

Function

FLRT1 is a cell adhesion molecule containing a fibronectin type III domain and a leucine-rich repeat (LRR) domain. The protein binds to other cell surface molecules, and also to the extracellular matrix. The FLRT family of proteins may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.

Clinical significance

Mutations in the FLRT1 gene have been associated with congenital short bowel syndrome (CSBS). CSBS is a severe, life-threatening condition that occurs when a large portion of the small intestine is missing or does not function properly.

Interactions

FLRT1 has been shown to interact with UNC5B, a netrin receptor. This interaction is thought to play a role in axon guidance during neural development.

See also

• Fibronectin leucine rich transmembrane protein
• Leucine-rich repeat
• Congenital short bowel syndrome
• UNC5B

External links

• FLRT1 at the National Center for Biotechnology Information