Factor V

Factor V is a protein of the coagulation system, usually existing as a molecule composed of a single chain, derived from its precursor protein, factor V. It is one of the critical substances that contribute to the proper coagulation of blood, a process that prevents excessive bleeding when the body is injured. Factor V is inactive in the circulation, and is activated by being cleaved by factor Xa, thrombin, or factor XIIa.

Function

Factor V acts as a critical cofactor for the enzyme prothrombinase by providing a large binding site for factor Xa. There are three forms of factor V; the active form, the inactive form, and the intermediate form. The active form is the one that functions in the coagulation cascade. The inactive form does not function in the coagulation cascade but is instead involved in the regulation of the amount of thrombin produced by the coagulation cascade. The intermediate form functions in the coagulation cascade but at a much slower rate than the active form.

Factor V Deficiency

Factor V Deficiency is a rare bleeding disorder that is inherited in an autosomal recessive manner. It is characterized by a deficiency in functional factor V, leading to a decrease in blood clotting. The symptoms of factor V deficiency include easy bruising, nosebleeds, bleeding gums, and prolonged bleeding from cuts. In severe cases, it can lead to life-threatening bleeding episodes.

Factor V Leiden

Factor V Leiden is a mutation of one of the clotting factors in the blood called factor V. This genetic mutation increases your chance of developing abnormal blood clotting, a condition known as thrombophilia. Most people with factor V Leiden never develop abnormal clots. However, some people with this mutation are at a slightly increased risk of developing blood clots.

See Also

• Coagulation
• Thrombophilia
• Blood clot
• Factor X
• Thrombin
• Factor XIIa

References

Factor V Resources
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