Factor V Leiden
Factor V Leiden is a mutation of one of the clotting factors in the blood called factor V. This mutation can increase your chance of developing abnormal blood clots (thrombophilia), which can lead to deep vein thrombosis (DVT).
Overview[edit | edit source]
Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels. People with factor V Leiden thrombophilia are at somewhat higher than average risk for a type of clot that forms in veins, such as the deep veins of the legs (deep venous thrombosis), or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism).
Causes[edit | edit source]
Factor V Leiden is a genetic disorder that is passed down through families. It is caused by a mutation of the Factor V gene, which is involved in the process of blood clotting. This mutation makes it harder for the body to break down blood clots, leading to an increased risk of developing a DVT.
Symptoms[edit | edit source]
Most people with factor V Leiden (FVL) never develop abnormal clots. However, some people with FVL develop clots that lead to long-term health problems or become life-threatening. Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen.
Diagnosis[edit | edit source]
If you have a family history of factor V Leiden and you have had one or more episodes of abnormal blood clotting, your doctor may suggest that you get a blood test to check for the disorder. The test checks for the presence of the factor V Leiden mutation in your blood.
Treatment[edit | edit source]
The main goals of treatment for factor V Leiden include preventing abnormal blood clotting and treating any clots that do develop. Treatment may include taking medication to thin the blood and prevent clots (anticoagulation), such as warfarin (Coumadin) or heparin.
See Also[edit | edit source]
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