Fau

Fau - a deoxyuridine prodrug with potential antineoplastic activity. Upon cellular uptake, 2' f ara deoxyuridine (fau) is phosphorylated by thymidine kinase to fau monophosphate and subsequently methylated in the 5' position by thymidylate synthase (ts) to its activated form, 1 (2 deoxy 2 fluoro beta d arabinofuranosyl) 5 methyluracil monophosphate (fmaump). Fmaump is incorporated into dna leading to an inhibition of dna synthesis and so cell growth. The catalytic activity of ts is critical to activation of fau and subsequent incorporation into dna. Fau may be beneficial in the case of tumors with high ts activity that are resistant to ts inhibitors.