Felypressin

Felypressin‏‎

File:Felypressin structure.png

Chemical structure of Felypressin

Felypressin is a synthetic non-catecholamine vasopressin analogue that is commonly used in dentistry and oral surgery as a vasoconstrictor. It is a derivative of vasopressin, also known as antidiuretic hormone (ADH), which plays a key role in regulating water balance in the body.

Pharmacology

Felypressin acts primarily on V1 receptors, leading to vasoconstriction of blood vessels. This results in increased blood pressure and reduced blood flow to the site of administration, making it an effective local hemostatic agent. It also has some vasopressin-like effects on V2 receptors, which can lead to antidiuretic effects.

Clinical Uses

In dentistry, Felypressin is commonly used in local anesthesia solutions to prolong the anesthetic effect and reduce bleeding during procedures such as tooth extractions and periodontal surgery. Its vasoconstrictive properties help to minimize bleeding, which can improve visibility and facilitate the dental procedure.

Side Effects

Common side effects of Felypressin include transient hypertension, tachycardia, and local tissue necrosis if injected intravascularly. It is important for healthcare providers to use the appropriate concentration and dosage to minimize the risk of adverse effects.

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