Fenamate

Fenamate is a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that are derived from fenamic acid. They are used to treat pain and inflammation associated with conditions such as arthritis, menstrual pain, and other types of acute or chronic pain.

History

Fenamates were first synthesized in the 1960s and have since been widely used in clinical practice. The first fenamate to be introduced was mefenamic acid, which remains one of the most commonly used drugs in this class.

Pharmacology

Fenamates work by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins. Prostaglandins play a key role in the body's inflammatory response, so by inhibiting their production, fenamates can reduce inflammation and pain.

Types of Fenamates

There are several different types of fenamates, including:

• Mefenamic acid
• Meclofenamic acid
• Flufenamic acid
• Tolfenamic acid

Each of these drugs has a slightly different chemical structure, but they all work in a similar way to reduce inflammation and pain.

Side Effects

Like all NSAIDs, fenamates can cause side effects. These can include gastrointestinal problems such as stomach pain, nausea, and ulcers, as well as kidney problems and an increased risk of heart attack or stroke.

Contraindications

Fenamates should not be used by people with certain health conditions, including those with a history of peptic ulcer disease, those with severe kidney or liver disease, and those with a history of heart attack or stroke. They should also not be used by people who are allergic to any other NSAIDs.

See Also

• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin