Fispemifene

From WikiMD's Wellnesspedia

Fispemifene is a synthetic steroid and selective estrogen receptor modulator (SERM) that is used in the treatment of male hypogonadism and osteoporosis in men. It is a nonsteroidal antiestrogen that is similar in structure and action to tamoxifen and raloxifene.

Mechanism of Action[edit | edit source]

Fispemifene acts as an antagonist at estrogen receptors in some tissues and as an agonist in others. In the prostate and breast, it acts as an antagonist, inhibiting the growth-promoting effects of estrogen. In bone and lipid metabolism, it acts as an agonist, mimicking the beneficial effects of estrogen.

Clinical Use[edit | edit source]

Fispemifene is used in the treatment of male hypogonadism, a condition characterized by low levels of testosterone and symptoms such as fatigue, depression, and sexual dysfunction. It is also used in the treatment of osteoporosis in men, a condition characterized by low bone mass and increased risk of bone fractures.

Side Effects[edit | edit source]

Common side effects of fispemifene include hot flashes, nausea, and vomiting. Less common side effects include breast pain, joint pain, and insomnia.

Pharmacokinetics[edit | edit source]

Fispemifene is well absorbed after oral administration and is extensively metabolized in the liver. It has a half-life of approximately 8 hours and is excreted primarily in the urine.

See Also[edit | edit source]

Resources[edit source]

Latest articles - Fispemifene

PubMed
Clinical trials
UpToDate

AI tools[edit source]

Generative AI tools and links to learn more on Fispemifene: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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