Fixed-dose procedure
Fixed-dose procedure is a method used in toxicology to classify the toxicity of substances. This procedure is used to determine the lethal dose of a substance that kills 50% of the test subjects, also known as the LD50.
Overview[edit | edit source]
The fixed-dose procedure was developed as an alternative to the LD50 test, which has been criticized for its use of large numbers of animals and for the severe distress caused to the test subjects. The fixed-dose procedure uses fewer animals and causes less distress.
Procedure[edit | edit source]
In the fixed-dose procedure, a group of animals is given a fixed dose of the substance under test. The dose is chosen to be likely to cause some toxicity but not to be lethal. The animals are then observed for a period of time, and any signs of toxicity are recorded. If no signs of toxicity are observed, the procedure is repeated with a higher dose. This continues until signs of toxicity are observed or until a maximum dose is reached.
Advantages and Disadvantages[edit | edit source]
The main advantage of the fixed-dose procedure is that it uses fewer animals and causes less distress than the LD50 test. However, it has been criticized for its lack of precision, as it does not provide an exact LD50 value.
See Also[edit | edit source]
| Fixed-dose procedure Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
