Fluticasone propionate

Fluticasone propionate is a synthetic corticosteroid derived from fluticasone, used to treat various inflammatory conditions such as asthma, allergic rhinitis, and eczema. The drug is available in several forms, including nasal sprays, inhalers, and creams.

Fluticasone propionate

Pharmacology and Mechanism of Action

Fluticasone propionate is a glucocorticoid receptor agonist that exerts its effects by binding to the cytosolic glucocorticoid receptor. This initiates a molecular process resulting in the suppression of pro-inflammatory genes and the enhancement of anti-inflammatory genes. The result is decreased inflammation and immune response, helping to manage symptoms in a range of inflammatory diseases.

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Metabolism and Excretion

Fluticasone propionate is metabolized in the liver by the enzyme Cytochrome P450 3A4 (CYP3A4). It is primarily excreted in the feces, with a small amount being excreted in urine.

Asthma

Fluticasone propionate is used as a maintenance treatment for asthma. It is delivered via inhalation to decrease inflammation in the airways, reducing the frequency and severity of asthma attacks.

Allergic Rhinitis

Fluticasone propionate nasal spray is used to treat symptoms of allergic rhinitis, such as sneezing, nasal congestion, and itchy or runny nose.

Eczema

Topical fluticasone propionate cream or ointment is used to reduce inflammation and relieve symptoms associated with eczema, such as itching, redness, and swelling.

side Effects and Contraindications

Common side effects of fluticasone propionate may include headache, throat irritation, and nosebleeds. Rare, but serious side effects may include adrenal suppression, growth retardation in children, and bone density loss with long-term use. Fluticasone propionate is contraindicated in individuals with hypersensitivity to fluticasone or any component of the formulation.

References

<references>

• "Fluticasone Propionate". Drug Information Portal. U.S. National Library of Medicine. Retrieved 2023-05-25.
• "Fluticasone Propionate". MedlinePlus Drug Information. U.S. National Library of Medicine. Retrieved 2023-05-25.
• "Fluticasone Propionate". Drugs.com. Retrieved 2023-05-25.
• Lipworth BJ. "Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis". Archives of Internal Medicine. 1999;159(9):941–55.

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