Fluticasone

From WikiMD's Wellness Encyclopedia

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Fluticasone is a synthetic glucocorticoid used to treat various inflammatory and allergic conditions. It is available in several forms, including inhalers, nasal sprays, and topical creams. Fluticasone is commonly prescribed for conditions such as asthma, allergic rhinitis, and dermatitis.

Medical Uses[edit | edit source]

Fluticasone is used in the management of several conditions:

Mechanism of Action[edit | edit source]

Fluticasone works by binding to the glucocorticoid receptor, which leads to the suppression of inflammatory mediators. This action reduces inflammation and immune responses, providing relief from symptoms associated with allergic and inflammatory conditions.

Side Effects[edit | edit source]

Common side effects of fluticasone include:

Serious side effects are rare but can include adrenal suppression and osteoporosis with long-term use.

Pharmacokinetics[edit | edit source]

Fluticasone has a high first-pass metabolism, which limits its systemic availability when administered via inhalation or nasal spray. It is metabolized primarily in the liver and excreted in the urine and feces.

Forms and Dosage[edit | edit source]

Fluticasone is available in various forms:

The dosage and form depend on the condition being treated and the patient's response to the medication.

History[edit | edit source]

Fluticasone was first approved for medical use in the early 1990s. It has since become a widely used medication for managing inflammatory and allergic conditions.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


Contributors: Prab R. Tumpati, MD