Flunixin

Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), specifically a pyrazolone derivative, used in veterinary medicine. It is primarily used to alleviate pain and inflammation associated with colic in horses, and for analgesia following surgical procedures in dogs and cats. It is also used as an anti-pyretic in cattle.

Pharmacology

Flunixin is a potent inhibitor of the enzyme cyclooxygenase, which is involved in the production of prostaglandins. Prostaglandins are lipid compounds that play a key role in inflammation and pain. By inhibiting cyclooxygenase, flunixin reduces the production of prostaglandins, thereby reducing inflammation and pain.

Usage

Flunixin is primarily used in horses for the alleviation of pain associated with colic. It is also used for analgesia following surgical procedures in dogs and cats. In cattle, it is used as an anti-pyretic to reduce fever.

Side Effects

The most common side effects of flunixin include gastrointestinal ulcers, kidney damage, and bleeding disorders. These side effects are more likely to occur with long-term use or at high doses.

Dosage and Administration

Flunixin is administered either orally or by injection. The dosage and frequency of administration depend on the species and condition being treated.

Contraindications

Flunixin should not be used in animals with known hypersensitivity to NSAIDs. It should also not be used in animals with severe kidney, liver, or heart disease, or in animals with bleeding disorders.

See Also

• Nonsteroidal anti-inflammatory drug
• Colic in horses
• Cyclooxygenase
• Prostaglandin