Fluorocitric acid

Fluorocitric acid

Fluorocitric acid is a fluorinated derivative of citric acid. It is a toxic compound that inhibits the tricarboxylic acid cycle, also known as the Krebs cycle or citric acid cycle, a key component of cellular respiration.

Chemistry

Fluorocitric acid is a fluorocarbon, a type of compound characterized by the presence of fluorine atoms. It is derived from citric acid, a tricarboxylic acid that plays a crucial role in the metabolism of all aerobic organisms. The substitution of a hydrogen atom with a fluorine atom in the citric acid molecule results in the formation of fluorocitric acid.

Toxicity

Fluorocitric acid is highly toxic due to its ability to inhibit the tricarboxylic acid cycle. This cycle is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into adenosine triphosphate (ATP) and carbon dioxide. Inhibition of this cycle disrupts cellular respiration, leading to cell death.

Symptoms and Treatment

Exposure to fluorocitric acid can result in a variety of symptoms, including nausea, vomiting, abdominal pain, and convulsions. In severe cases, it can lead to cardiac arrest and death. Treatment typically involves supportive care, including hydration and symptomatic treatment. There is no specific antidote for fluorocitric acid poisoning.

See Also

• Fluoroacetate
• Citric acid cycle
• Cellular respiration