Fluxapyroxad

Fluxapyroxad is a fungicide that belongs to the class of chemical compounds known as succinate dehydrogenase inhibitors (SDHIs). It is used in agriculture to control a wide range of plant pathogens, particularly those causing leaf spot diseases and rusts.

Chemistry

Fluxapyroxad is a synthetic compound with the chemical formula C_14H_11Cl_2N_3O_2. It is a member of the pyrazole class of compounds and is characterized by its ability to inhibit the enzyme succinate dehydrogenase, which is essential for energy production in cells.

Mode of Action

Fluxapyroxad works by inhibiting the enzyme succinate dehydrogenase in the mitochondria of fungal cells. This enzyme is involved in the citric acid cycle, also known as the Krebs cycle, which is a key process in cellular respiration. By blocking this enzyme, fluxapyroxad disrupts energy production in the fungal cell, leading to cell death.

Uses

Fluxapyroxad is used in a variety of agricultural settings to control fungal diseases. It is particularly effective against diseases caused by ascomycete fungi, including powdery mildew, leaf spots, and rusts. It is often used in combination with other fungicides to improve efficacy and manage fungicide resistance.

Safety and Environmental Impact

Fluxapyroxad is considered to have low toxicity to mammals, but it can be harmful to aquatic organisms. It is not considered to be a carcinogen or mutagen, but it can cause eye irritation. In the environment, it is moderately persistent and has potential for bioaccumulation.

Regulation

In the European Union, fluxapyroxad was approved for use as a fungicide in 2012. In the United States, it is registered for use by the Environmental Protection Agency (EPA).

File:Fluxapyroxad.png

Chemical structure of fluxapyroxad

See Also

• Fungicide
• Succinate dehydrogenase inhibitor
• Pyrazole
• Citric acid cycle