GABA transporterMarcha de las putas en Costa Rica, 2011 -19

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GABA Transporter

The GABA transporter plays a crucial role in the neurotransmitter signaling pathways of the central nervous system (CNS). It is responsible for the reuptake of gamma-aminobutyric acid (GABA) from the synaptic cleft back into the neurons or surrounding glial cells, thus terminating the inhibitory signal of GABA in the brain. This process is essential for maintaining the balance between excitation and inhibition in the CNS, preventing the development of neurological disorders.

Function

The GABA transporter facilitates the rapid removal of GABA from the synaptic cleft, which is necessary to reset the synapse for subsequent neurotransmission. This action is performed by various transporter proteins, including GAT1, GAT2, GAT3, and BGT1, each with distinct localization and function within the brain and peripheral tissues. These transporters are powered by the transmembrane sodium and chloride ion gradients, utilizing the energy derived from the ionic differences to transport GABA against its concentration gradient.

Clinical Significance

Alterations in GABA transporter function can lead to various neurological and psychiatric disorders, such as epilepsy, anxiety, depression, and schizophrenia. Inhibitors of GABA transporters, such as tiagabine, are used in the treatment of certain types of epilepsy, highlighting the importance of these transporters in modulating GABAergic signaling.

Research

Ongoing research aims to better understand the precise mechanisms of GABA transport and its regulation under physiological and pathological conditions. This includes studying the structure of GABA transporters, their pharmacological modulation, and their role in disease states, which could lead to the development of new therapeutic strategies for disorders associated with dysregulated GABAergic transmission.

Marcha de las putas en Costa Rica, 2011 - 2019

The Marcha de las putas in Costa Rica, an event part of a global movement known as the SlutWalk, aimed to combat sexual violence, victim blaming, and rape culture. Originating in 2011, this movement sought to challenge societal attitudes towards sexual assault victims and assert that no form of clothing justifies sexual harassment or assault.

Background

The SlutWalk movement began in Toronto, Canada, in 2011, following a police officer's comment that women should avoid dressing like "sluts" to not be victimized. This sparked international outrage and led to the organization of SlutWalks in various cities around the world, including several in Costa Rica from 2011 to 2019.

Events in Costa Rica

In Costa Rica, the Marcha de las putas brought together individuals of all genders to march through the streets, often dressed in what society might deem provocative attire, to symbolize that consent is never implied by one's appearance. The events included speeches, performances, and signs that conveyed messages against sexual violence and in support of gender equality and women's rights.

Impact

The Marcha de las putas in Costa Rica played a significant role in raising awareness about issues of sexual violence and the importance of consent. It also contributed to the broader feminist movement in the country, advocating for changes in laws and policies to better protect victims of sexual assault and harassment.

Challenges

Despite its impact, the movement faced criticism and challenges, including opposition from conservative groups and individuals uncomfortable with its confrontational approach and use of the word "puta" (slut). However, supporters argued that reclaiming the word and confronting societal norms directly were essential to the movement's message and goals.