GABBR2

GABBR2 is a gene that encodes the GABA B receptor subtype 2 protein in humans. It is located on chromosome 9 and is involved in the neurotransmission process. The GABBR2 gene is associated with several neurological and psychiatric disorders, including schizophrenia, bipolar disorder, and addiction.

Function

The GABBR2 gene encodes the GABA B receptor subtype 2, which is a member of the G-protein coupled receptor family. This receptor is found predominantly in the central nervous system and is responsible for mediating the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mammalian brain.

Clinical significance

Alterations in the GABBR2 gene have been associated with a variety of neurological and psychiatric disorders. For example, several studies have found a link between variations in the GABBR2 gene and the development of schizophrenia and bipolar disorder. Additionally, mutations in this gene have been implicated in the pathogenesis of addiction.

Research

Research into the GABBR2 gene and its associated protein continues to be a significant area of interest in neuroscience and psychiatry. Understanding the role of this gene in neurotransmission and its potential involvement in psychiatric disorders could lead to the development of new therapeutic strategies.

See also

• GABA B receptor
• G-protein coupled receptor
• Neurotransmission
• Schizophrenia
• Bipolar disorder
• Addiction

References

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