GPER

GPER (G Protein-Coupled Estrogen Receptor 1) is a protein that in humans is encoded by the GPER gene. It is a member of the G protein-coupled receptor family and is involved in various physiological processes.

Function

GPER is a cell membrane receptor that binds estrogen, a type of steroid hormone. Upon binding, it activates a G protein, which in turn triggers a series of cellular responses. These responses can include changes in gene expression, cell growth, and cell differentiation. GPER is expressed in various tissues, including the heart, brain, and reproductive system.

Clinical significance

GPER has been implicated in a number of diseases, including breast cancer, ovarian cancer, and endometrial cancer. It is thought to play a role in the growth and progression of these cancers. In addition, GPER has been linked to cardiovascular disease, as it is involved in the regulation of blood pressure and heart rate.

Research

Research into GPER is ongoing, with studies focusing on its role in disease and its potential as a therapeutic target. For example, drugs that can selectively activate or inhibit GPER are being developed and tested for their ability to treat various diseases.

See also

• Estrogen receptor
• G protein-coupled receptor
• Steroid hormone

References

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