GPIIb
GPIIb (Glycoprotein IIb) is a protein that in humans is encoded by the ITGA2B gene. It is a part of the integrin alpha chain family and is known to combine with ITGB3 to form a platelet glycoprotein complex. This complex plays a crucial role in the process of blood coagulation and platelet aggregation.
Function[edit | edit source]
GPIIb, in combination with ITGB3, forms the GPIIb/IIIa complex. This complex is a receptor for fibrinogen, von Willebrand factor, fibronectin, and vitronectin. It is responsible for platelet adhesion and aggregation, which are essential steps in the process of blood coagulation.
Clinical significance[edit | edit source]
Mutations in the ITGA2B gene can lead to disorders such as Glanzmann's thrombasthenia, which is characterized by a lack of platelet aggregation. This can result in prolonged bleeding times and a tendency towards excessive bleeding.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
