GPIIb

GPIIb (Glycoprotein IIb) is a protein that in humans is encoded by the ITGA2B gene. It is a part of the integrin alpha chain family and is known to combine with ITGB3 to form a platelet glycoprotein complex. This complex plays a crucial role in the process of blood coagulation and platelet aggregation.

Function

GPIIb, in combination with ITGB3, forms the GPIIb/IIIa complex. This complex is a receptor for fibrinogen, von Willebrand factor, fibronectin, and vitronectin. It is responsible for platelet adhesion and aggregation, which are essential steps in the process of blood coagulation.

Clinical significance

Mutations in the ITGA2B gene can lead to disorders such as Glanzmann's thrombasthenia, which is characterized by a lack of platelet aggregation. This can result in prolonged bleeding times and a tendency towards excessive bleeding.

See also

• Integrin
• ITGB3
• Glanzmann's thrombasthenia

External links

• NCBI Gene

GPIIb Resources
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