GPR176

GPR176 is a gene that encodes the G Protein-Coupled Receptor 176 in humans. This receptor is a part of the G protein-coupled receptor family, which is a large family of cell surface receptors that respond to various external signals.

Function

The GPR176 protein is an orphan receptor, meaning its endogenous ligand is currently unknown. It is thought to play a role in the regulation of circadian rhythm, as studies have shown it to be a potent regulator of the suprachiasmatic nucleus, the body's central circadian clock.

Clinical Significance

While the exact role of GPR176 in human health and disease is still being researched, it has been implicated in several medical conditions. For example, alterations in the GPR176 gene have been associated with sleep disorders, due to its role in regulating circadian rhythm. Additionally, it has been suggested that GPR176 may play a role in neurodegenerative diseases, although further research is needed to confirm this.

Research

Research into GPR176 is ongoing, with scientists seeking to better understand its function and potential role in disease. This includes research into its potential as a therapeutic target for conditions such as sleep disorders and neurodegenerative diseases.

See Also

• G protein-coupled receptors
• Circadian rhythm
• Suprachiasmatic nucleus
• Sleep disorders
• Neurodegenerative diseases