GPR183

GPR183 (G Protein-Coupled Receptor 183), also known as EBI2 (Epstein-Barr Virus Induced Gene 2), is a protein that in humans is encoded by the GPR183 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in the immune system.

Function

GPR183 is a G protein-coupled receptor that is involved in the regulation of B cell function. It is expressed in various tissues with high levels in lymphoid tissues such as spleen, lymph node, and peripheral blood leukocytes. The receptor is activated by a lipid molecule called 7α,25-dihydroxycholesterol (7α,25-OHC) which is synthesized in response to inflammatory signals. This activation leads to the migration of B cells and other immune cells to the inflamed tissues.

Clinical Significance

Alterations in the GPR183 gene have been associated with various diseases. Overexpression of GPR183 has been observed in Hodgkin's lymphoma and diffuse large B cell lymphoma, suggesting a potential role in the pathogenesis of these diseases. In addition, GPR183 has been implicated in autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus.

Research

Research is ongoing to understand the precise role of GPR183 in the immune system and its potential as a therapeutic target. Studies have shown that blocking the activity of GPR183 can reduce the severity of autoimmune diseases in animal models, suggesting a potential therapeutic strategy for these conditions.

See Also

• G protein-coupled receptor
• B cell
• Hodgkin's lymphoma
• Multiple sclerosis