Diffuse Large B-Cell Lymphoma[edit | edit source]

Microscopy image of diffuse large B-cell lymphoma, showing characteristic cell morphology.

Diffuse Large B-Cell Lymphoma[edit | edit source]

Diffuse large B-cell lymphoma (DLBCL) is a type of B-cell non-Hodgkin lymphoma, which is a cancer of the immune system. It is known for being aggressive, or fast-growing, and is the most common type of non-Hodgkin lymphoma. DLBCL typically manifests as rapidly enlarging tumors in the lymph nodes, spleen, liver, bone marrow, or other organs.

Symptoms[edit | edit source]

Common symptoms of DLBCL include:

Fever
Night sweats
Weight loss
Enlarged lymph nodes
Fatigue
Loss of appetite

Subtypes of DLBCL[edit | edit source]

DLBCL can be classified into several subtypes based on genetic, molecular, and clinical features, including:

Germinal Center B-cell-like (GCB)
Activated B-cell-like (ABC)
Primary Mediastinal B-cell lymphoma
Others, as identified through advanced molecular and genetic testing

Diagnosis[edit | edit source]

Diagnosing DLBCL involves:

Physical examination, particularly of the lymph nodes
Laboratory tests including complete blood count (CBC) and lactate dehydrogenase (LDH) levels
Imaging studies such as CT scans and PET scans
Biopsy of the lymph node or other affected tissues

Treatment[edit | edit source]

Treatment for DLBCL generally includes:

Chemotherapy, often combined with the monoclonal antibody Rituximab
In some cases, Radiation therapy may be used
Advanced cases may require bone marrow or stem cell transplantation

Prognosis[edit | edit source]

The prognosis for DLBCL varies based on factors such as:

Age and overall health of the patient
Stage of the lymphoma at diagnosis
Response to initial treatment
Specific subtype of DLBCL

Ongoing Research[edit | edit source]

Research into DLBCL is focused on:

Developing targeted therapies
Improving the effectiveness of current treatments
Understanding the genetic and molecular basis of the disease

Diffuse large B-cell lymphoma Resources
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