GPRC5A

GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) is a protein that in humans is encoded by the GPRC5A gene. It is a member of the G protein-coupled receptor family, which is a large family of cell surface receptors that respond to various external stimuli and play a crucial role in many physiological processes.

Function

GPRC5A is a retinoic acid inducible gene, and it is believed to play a role in non-small cell lung carcinoma (NSCLC). The protein is a member of the class C group of G protein-coupled receptors, which are characterized by an evolutionarily conserved protein motif. The GPRC5A protein lacks the conserved DRY motif and instead has a TTY motif, making it a unique member of this family.

Clinical significance

GPRC5A has been found to be overexpressed in lung cancer, particularly in non-small cell lung carcinoma. It is believed that the overexpression of this protein may contribute to the growth and survival of these tumor cells. Additionally, GPRC5A has been implicated in the development of other types of cancer, including breast cancer and pancreatic cancer.

Research

Research into the function and potential therapeutic applications of GPRC5A is ongoing. Current research is focused on understanding the role of this protein in cancer development and progression, as well as exploring its potential as a therapeutic target for cancer treatment.

See also

• G protein-coupled receptor
• Non-small cell lung carcinoma
• Retinoic acid

References

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