GRAMD4

GRAMD4 (GRAM Domain Containing 4) is a protein that in humans is encoded by the GRAMD4 gene. This protein is a member of the GRAM domain family, a group of proteins characterized by a unique, highly conserved domain that is involved in protein-protein interactions.

Function

The GRAMD4 protein is believed to play a role in apoptosis, a process of programmed cell death. It is thought to function as a pro-apoptotic factor, promoting cell death in response to various stimuli. This is supported by studies showing that overexpression of GRAMD4 can induce apoptosis in certain cell types.

Clinical significance

Alterations in the GRAMD4 gene have been associated with several types of cancer, including breast cancer and lung cancer. These alterations can lead to changes in the function of the GRAMD4 protein, potentially contributing to the development and progression of cancer. However, further research is needed to fully understand the role of GRAMD4 in cancer and other diseases.

See also

• GRAM domain
• Apoptosis
• Gene
• Protein