GRB10

GRB10 (Growth Factor Receptor-Bound Protein 10) is a protein that in humans is encoded by the GRB10 gene. This protein is a member of the GRB7 family and was first identified as a binding partner for the insulin receptor tyrosine kinase.

Function

GRB10 is an intracellular adapter protein that is known to play a role in cellular growth responses. It is thought to act by binding to receptor tyrosine kinases and inhibiting their activities. This protein interacts with insulin receptors and insulin-like growth factor receptors, thus it is likely involved in the regulation of growth and metabolism.

Clinical significance

Mutations in the GRB10 gene have been associated with diabetes mellitus type 2 and insulin resistance. Studies have also suggested a role for GRB10 in the regulation of fetal growth and development. Overexpression of this gene has been observed in several types of cancer, including breast and prostate cancer.

Structure

The GRB10 protein consists of several domains, including a pleckstrin homology domain (PH domain), a BPS domain, and a SH2 domain. The PH domain is responsible for binding to phosphoinositides, while the BPS domain interacts with the insulin receptor. The SH2 domain is responsible for binding to phosphorylated tyrosine residues on activated receptor tyrosine kinases.

See also

• GRB7
• Insulin receptor
• Diabetes mellitus type 2
• Insulin resistance