GRIK2

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GRIK2 or Glutamate Ionotropic Receptor Kainate Type Subunit 2 is a protein that in humans is encoded by the GRIK2 gene. It is a member of the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.

Function[edit | edit source]

The protein encoded by the GRIK2 gene is a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity, a process that underlies learning and memory. It is thought to interact with other proteins, like Neto1 and Neto2, to regulate kainate receptor function.

Clinical significance[edit | edit source]

Mutations in the GRIK2 gene have been associated with several neurological disorders, including autism, schizophrenia, and bipolar disorder. Studies have also suggested a potential role in the development and progression of Parkinson's disease.

Structure[edit | edit source]

The GRIK2 protein is a transmembrane protein, meaning it spans the membrane of the cells in which it is expressed. It is composed of several domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to glutamate, while the transmembrane domain forms the ion channel.

See also[edit | edit source]

References[edit | edit source]


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