GTF3C1

GTF3C1 is a gene that encodes a protein involved in RNA polymerase III transcription. It is a part of the General Transcription Factor IIIC group, which is a complex necessary for transcription of genes by RNA polymerase III. The GTF3C1 protein is a subunit of this complex and plays a crucial role in the initiation of transcription.

Function

The GTF3C1 gene provides instructions for making a protein that is a part of a larger complex known as the General Transcription Factor IIIC. This complex is involved in the initiation of transcription, a process that involves copying DNA into RNA. The GTF3C1 protein specifically helps to bind the complex to DNA and initiate transcription.

Clinical Significance

Mutations in the GTF3C1 gene have been associated with various diseases. For instance, some studies have suggested a link between alterations in this gene and cancer. However, more research is needed to fully understand the role of GTF3C1 in disease development and progression.

See Also

• Transcription (genetics)
• RNA polymerase III
• General Transcription Factor IIIC

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