GTF3C2

GTF3C2 is a gene that encodes a subunit of the general transcription factor IIIC (TFIIIC) complex, which is essential for the transcription of genes by RNA polymerase III. The TFIIIC complex is involved in the transcription of tRNA, 5S rRNA, and other small RNAs. The GTF3C2 protein plays a crucial role in the assembly and function of the TFIIIC complex.

Function

The primary function of the GTF3C2 protein is to facilitate the binding of the TFIIIC complex to the DNA promoter regions of genes transcribed by RNA polymerase III. This binding is necessary for the recruitment of other transcription factors and the initiation of transcription. The TFIIIC complex recognizes and binds to specific promoter elements, such as the A box and B box within the tRNA and 5S rRNA genes.

Structure

The GTF3C2 protein is one of the six subunits of the TFIIIC complex. The other subunits include GTF3C1, GTF3C3, GTF3C4, GTF3C5, and GTF3C6. Each subunit has a specific role in the assembly and function of the complex. The GTF3C2 subunit is known for its role in stabilizing the interaction between the TFIIIC complex and the DNA promoter regions.

Clinical Significance

Mutations in the GTF3C2 gene have been associated with various genetic disorders. These mutations can lead to defects in the transcription of tRNA and 5S rRNA, which are essential for protein synthesis and cellular function. Research is ongoing to understand the full spectrum of diseases associated with GTF3C2 mutations and their underlying mechanisms.

Related Pages

• RNA polymerase III
• Transcription factor
• tRNA
• 5S rRNA
• DNA
• Promoter (genetics)
• A box
• B box

See Also

• GTF3C1
• GTF3C3
• GTF3C4
• GTF3C5
• GTF3C6