GW-0742
GW-0742 is a drug that acts as a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), and has been investigated for its potential to treat cardiovascular disease, diabetes, and metabolic syndrome. It is a member of the class of drugs known as PPAR modulators.
Pharmacology[edit | edit source]
GW-0742 is a potent and highly selective PPARδ agonist, with a Ki of 1 nM for human PPARδ and >1000-fold selectivity over PPARα and PPARγ. It is orally active and has been shown to have anti-inflammatory and anti-fibrotic activity, as well as the ability to improve insulin sensitivity in animal studies.
Clinical Trials[edit | edit source]
GW-0742 has been investigated in clinical trials for its potential to treat various conditions. In a study on patients with type 2 diabetes, it was found to improve insulin sensitivity and reduce blood glucose levels. In another study on patients with metabolic syndrome, it was found to reduce triglyceride levels and increase HDL cholesterol levels.
Potential Therapeutic Uses[edit | edit source]
Due to its anti-inflammatory and anti-fibrotic activity, GW-0742 has potential therapeutic uses in the treatment of a variety of conditions. These include cardiovascular disease, diabetes, metabolic syndrome, and potentially other conditions associated with inflammation and fibrosis.
Side Effects[edit | edit source]
As with all drugs, GW-0742 has the potential to cause side effects. These may include nausea, vomiting, diarrhea, and abdominal pain. However, these side effects are generally mild and manageable.
See Also[edit | edit source]
- Peroxisome proliferator-activated receptor
- PPAR modulator
- Cardiovascular disease
- Diabetes
- Metabolic syndrome
GW-0742 Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD