Gabazine
Gabazine[edit | edit source]
Gabazine, also known as SR-95531, is a potent GABA_A receptor antagonist. It is primarily used in neuroscience research to study the role of GABAergic inhibition in the central nervous system. Gabazine is a competitive antagonist that binds to the GABA binding site on the GABA_A receptor, thereby inhibiting the action of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain.
Mechanism of Action[edit | edit source]
Gabazine functions by blocking the GABA_A receptor, which is a ligand-gated ion channel that mediates inhibitory synaptic transmission in the central nervous system. When GABA binds to the GABA_A receptor, it typically causes the channel to open, allowing chloride ions to flow into the neuron, leading to hyperpolarization and inhibition of neuronal firing. Gabazine competes with GABA for binding to the receptor, preventing the opening of the chloride channel and thus reducing inhibitory synaptic transmission.
Applications in Research[edit | edit source]
Gabazine is widely used in neuroscience research to investigate the role of GABAergic inhibition in various physiological and pathological processes. By blocking GABA_A receptors, researchers can study the effects of reduced inhibition on neuronal circuits, synaptic plasticity, and neural network activity. Gabazine is also used to explore the mechanisms underlying epilepsy, anxiety, and other neurological disorders where GABAergic signaling is disrupted.
Pharmacology[edit | edit source]
Gabazine is a selective antagonist for the GABA_A receptor and does not significantly affect other types of GABA receptors, such as GABA_B receptors. Its selectivity makes it a valuable tool for dissecting the specific contributions of GABA_A receptor-mediated inhibition in various experimental models.
Safety and Handling[edit | edit source]
As with many research chemicals, gabazine should be handled with care. It is important to follow appropriate safety protocols, including the use of personal protective equipment and proper disposal methods, to minimize exposure and environmental impact.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD