Gamma-Hydroxybutyraldehyde

Gamma-Hydroxybutyraldehyde (also known as GHBAL) is a chemical compound that is a precursor in the biosynthesis of GHB. It is formed from GABA through the action of the enzyme GABA transaminase and is then converted to GHB through the action of the enzyme succinic semialdehyde reductase.

Chemistry[edit | edit source]

Gamma-Hydroxybutyraldehyde is a aldehyde with the chemical formula C4H8O2. It is a colorless liquid that is soluble in water and organic solvents. The compound has a strong, pungent odor and is highly reactive due to the presence of the aldehyde functional group.

Biosynthesis[edit | edit source]

In the human body, gamma-Hydroxybutyraldehyde is produced from GABA through the action of the enzyme GABA transaminase. This reaction also produces succinic semialdehyde. Gamma-Hydroxybutyraldehyde is then converted to GHB by the enzyme succinic semialdehyde reductase.

Pharmacology[edit | edit source]

Gamma-Hydroxybutyraldehyde is not active in the body on its own, but it is a precursor to GHB, a substance that has both therapeutic and recreational uses. GHB is a central nervous system depressant that is used medically for the treatment of narcolepsy and alcohol withdrawal. It is also used recreationally for its euphoric and sedative effects.

Toxicity[edit | edit source]

Exposure to gamma-Hydroxybutyraldehyde can cause irritation to the eyes, skin, and respiratory tract. Ingestion or inhalation of large amounts can lead to nausea, vomiting, and central nervous system depression.