Gamma-glutamyltransferase 6

Gamma-glutamyltransferase 6 (GGT6) is an enzyme that in humans is encoded by the GGT6 gene. It is a member of the gamma-glutamyltransferase (GGT) family, which are enzymes involved in the metabolism of glutathione and other amino acids.

Function

The GGT6 enzyme is involved in the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). This process is crucial in the body's metabolism of glutathione, a powerful antioxidant that helps protect cells from damage by free radicals.

Structure

The GGT6 gene is located on the long (q) arm of chromosome 20 at position 11.2. The encoded protein is 567 amino acids long with a predicted molecular weight of approximately 62 kDa.

Clinical significance

Alterations in GGT6 activity have been associated with various diseases, including liver disease, cardiovascular disease, and certain types of cancer. Elevated levels of GGT6 can be a marker for liver disease and have been associated with increased risk of cardiovascular disease.

See also

• Gamma-glutamyltransferase
• Glutathione metabolism
• Liver disease
• Cardiovascular disease