Gamma-glutamyltransferase 6

Gamma-glutamyltransferase 6 (GGT6) is an enzyme that in humans is encoded by the GGT6 gene. It is a member of the gamma-glutamyltransferase (GGT) family, which are enzymes involved in the metabolism of glutathione and other amino acids.

Function[edit | edit source]

The GGT6 enzyme is involved in the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). This process is crucial in the body's metabolism of glutathione, a powerful antioxidant that helps protect cells from damage by free radicals.

Structure[edit | edit source]

The GGT6 gene is located on the long (q) arm of chromosome 20 at position 11.2. The encoded protein is 567 amino acids long with a predicted molecular weight of approximately 62 kDa.

Clinical significance[edit | edit source]

Alterations in GGT6 activity have been associated with various diseases, including liver disease, cardiovascular disease, and certain types of cancer. Elevated levels of GGT6 can be a marker for liver disease and have been associated with increased risk of cardiovascular disease.