Gamma interferon

Gamma Interferon (also known as Interferon gamma, IFN-γ, or Type II interferon) is a type of protein that is produced by lymphocytes and is classified as a cytokine. It plays a crucial role in the immune system, particularly in the body's defense against viral infections and tumors.

Function

Gamma Interferon is primarily produced by Natural Killer (NK) cells and T cells in response to an infection. It is a key player in the immune response, activating macrophages and inducing mechanisms to eliminate pathogens. It also has a role in inflammation, autoimmune diseases, and cancer.

Structure

Gamma Interferon is a dimeric protein, meaning it is composed of two identical subunits. Each subunit is made up of six alpha helices. The structure of Gamma Interferon is unique among interferons and is characterized by its compact, globular shape.

Clinical Significance

Gamma Interferon has been used in the treatment of several diseases, including chronic granulomatous disease and osteopetrosis. It is also being studied for its potential use in treating various forms of cancer. However, its use can be associated with severe side effects, including flu-like symptoms, depression, and autoimmune diseases.

See Also

• Interferon
• Cytokine
• Immune system
• Inflammation
• Cancer