Ganirelix
Ganirelix is a decapeptide and a potent, competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovarian hyperstimulation syndrome (OHSS).
Mechanism of Action[edit | edit source]
Ganirelix works by blocking the action of gonadotropin-releasing hormone (GnRH) on the pituitary gland. GnRH stimulates the pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the ovaries to produce eggs and release estrogen. By blocking this action, Ganirelix prevents premature ovulation that can result in the release of eggs that are not ready for fertilization.
Uses[edit | edit source]
Ganirelix is used in fertility treatment to prevent premature ovulation in women undergoing controlled ovarian hyperstimulation (COH), as part of an assisted reproductive technology (ART) program. It allows for the timing of the luteinizing hormone surge, and consequently, the timing of ovulation, providing optimal conditions for fertilization and implantation.
Side Effects[edit | edit source]
Common side effects of Ganirelix include abdominal pain, headache, vaginal bleeding, and nausea. In rare cases, it can cause Ovarian Hyperstimulation Syndrome (OHSS), a condition where the ovaries swell and cause abdominal pain.
Contraindications[edit | edit source]
Ganirelix is contraindicated in women who are pregnant, have hypersensitivity to Ganirelix or any of its components, or have severe renal impairment.
See Also[edit | edit source]
- Gonadotropin-releasing hormone antagonist
- Assisted reproductive technology
- Ovarian hyperstimulation syndrome
Resources[edit source]
Latest articles - Ganirelix
AI tools[edit source]
Generative AI tools and links to learn more on Ganirelix: ChatGPT - Bing Chat - Google Gemini. (caution advised).
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