Gastrin-releasing peptide receptor

Gastrin-releasing peptide receptor (GRPR), also known as BB2, is a protein that in humans is encoded by the GRPR gene. This receptor is a member of the bombesin receptor family. It is primarily found in the pancreas, stomach, and central nervous system.

Function

The GRPR is a G protein-coupled receptor that binds bombesin-like peptides such as gastrin-releasing peptide (GRP). GRP is a 27-amino acid peptide that is primarily released by the stomach during digestion. It stimulates the release of gastrin and other gastrointestinal hormones, and it also plays a role in inflammation and pain.

Clinical significance

Alterations in GRPR function have been associated with several diseases, including cancer. Overexpression of GRPR has been observed in various types of cancer, including breast cancer, prostate cancer, and lung cancer. This overexpression often correlates with a worse prognosis. GRPR antagonists are being investigated as potential cancer therapeutics.

See also

• Bombesin receptor
• Gastrin-releasing peptide
• G protein-coupled receptor

External links

• GRPR at HUGO Gene Nomenclature Committee
• GRPR at UniProtKB