Gemazocine

Gemazocine is a benzomorphan derivative used in opioid research. Gemazocine is an opioid analgesic which has been used in studies on opioid receptor function and opioid analgesic drugs. It is a mixed agonist-antagonist for μ-opioid receptors and κ-opioid receptors, acting as an antagonist at the former and an agonist at the latter.

Chemistry

Gemazocine is a member of the benzomorphan class of opioids. It is structurally related to other benzomorphans such as pentazocine, phenazocine, and cyclazocine, but has a unique profile of effects due to its mixed agonist-antagonist activity at different opioid receptors.

Pharmacology

Gemazocine acts as an agonist at κ-opioid receptors, which are involved in pain perception, stress response, and mood regulation. It also acts as an antagonist at μ-opioid receptors, which are primarily responsible for the analgesic effects of opioids. This mixed activity gives gemazocine a unique profile of effects, which can include analgesia, dysphoria, and hallucinations.

Research

Gemazocine has been used in research to study the function of opioid receptors and the effects of various opioid analgesic drugs. It has been particularly useful in studies on the role of κ-opioid receptors in pain perception and mood regulation.

See also

• Benzomorphan
• Opioid receptor
• Opioid analgesic

Gemazocine Resources
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