Gemeprost

Gemeprost is a synthetic analogue of prostaglandin E1 (PGE1) that is used as a medication. It is an abortifacient, which means it can induce abortion, and it is also used in the treatment of cervical ripening before surgical abortion.

Medical Uses

Gemeprost is used in medicine for two main purposes. The first is as an abortifacient, in combination with mifepristone, for the termination of pregnancy up to 63 days gestation. The second use is for the preparation of the cervix for surgical abortion.

Mechanism of Action

Gemeprost works by interacting with prostaglandin E receptors. This interaction leads to a series of events that result in the softening, dilation, and effacement of the cervix, which are necessary for childbirth and abortion. In addition, gemeprost stimulates the contraction of the uterus, which helps to expel the pregnancy.

Side Effects

The most common side effects of gemeprost include nausea, vomiting, diarrhea, and abdominal pain. Other side effects can include fever, chills, headache, and dizziness. In rare cases, gemeprost can cause severe allergic reactions.

Contraindications

Gemeprost is contraindicated in patients with known hypersensitivity to prostaglandins. It should not be used in patients with asthma, glaucoma, or cardiovascular disease without careful consideration of the risks and benefits.

See Also

• Prostaglandin E1
• Mifepristone
• Abortion

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