Glucagon-like peptide-2 receptor

Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in humans is encoded by the GLP2R gene. It is a member of the glucagon receptor family of G protein-coupled receptors.

Function

The GLP-2R is a receptor for the glucagon-like peptide 2 (GLP-2). Upon binding, GLP-2 stimulates intestinal growth and upregulates villus height in the small intestine, increases nutrient absorption and reduces inflammation. It is an important factor in the intestinal adaptation that occurs in response to the resection of the small intestine.

Clinical significance

Mutations in the GLP2R gene are associated with a rare congenital disorder of gastrointestinal absorption. This disorder, known as intestinal pseudo-obstruction, is characterized by abnormalities in the nerves of the intestines, leading to severe digestive problems.

GLP-2R is also a potential therapeutic target for inflammatory bowel disease (IBD) and short bowel syndrome (SBS). GLP-2 analogs that activate the GLP-2R have been shown to improve intestinal function in patients with these conditions.

See also

• Glucagon-like peptide 1 receptor
• Glucagon-like peptide 2

References

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